Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor

MeSH terms

• Amino Acid Sequence
• Fibrinogen / metabolism
• Fibrinogen / pharmacology*
• Molecular Sequence Data
• Oligopeptides / chemical synthesis
• Oligopeptides / pharmacology*
• Platelet Aggregation / drug effects*
• Platelet Aggregation Inhibitors / chemical synthesis
• Platelet Aggregation Inhibitors / pharmacology*
• Platelet Glycoprotein GPIb-IX Complex*
• Platelet Membrane Glycoproteins*
• Receptors, Immunologic / drug effects
• Receptors, Immunologic / metabolism
• Structure-Activity Relationship